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Today’s evolving HSCT landscape requires… READINESS. RECOGNITION. REACTION.

Increased vigilance is key to identifying veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS)

Explore current diagnostic criteria

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Risk factors for VOD/SOS

Know risk factors that can lead to VOD/SOS, a potentially life-threatening and rapidly progressing complication1-3

Risk factors

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Signs and symptoms of VOD/SOS progression

Be ready to act by knowing the signs and symptoms of rapidly progressing VOD/SOS1,4,5

Signs and symptoms

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An in-depth look at the complex pathogenesis of VOD/SOS

Take a closer look at the processes involved in the development of VOD/SOS

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HSCT=hematopoietic stem-cell transplantation; SOS=sinusoidal obstruction syndrome; VOD=veno-occlusive disease.

References: 1. Coppell JA, Richardson PG, Soiffer R, et al. Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome. Biol Blood Marrow Transplant. 2010;16(2):157-168. 2. Carreras E, Díaz-Beyá M, Rosiñol L, et al. The incidence of veno-occlusive disease following allogeneic hematopoietic stem cell transplantation has diminished and the outcome improved over the last decade. Biol Blood Marrow Transplant. 2011;17(11):1713-1720. 3. Richardson PG, Ho VT, Cutler C, et al. Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: novel insights to pathogenesis, current status of treatment, and future directions. Biol Blood Marrow Transplant. 2013;19 (suppl 1):S88-S90. 4. McDonald GB, Hinds MS, Fisher LD, et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med. 1993;118(4):255-267. 5. Bearman SI. The syndrome of hepatic veno-occlusive disease after marrow transplantation. Blood. 1995;85(11):3005-3020.